Всероссийский научно-исследовательский институт физиологии, биохимии и питания животных – филиал Федерального государственного бюджетного научного учреждения «Федеральный научный центр животноводства – ВИЖ имени академика Л.К. Эрнста»
There was evaluated a potential possibility for using yeast mitochondria in studies of oxidative stress in animals. The main parts of the report: production and characterization of mitochondria yeast preparations of Yarrowia lipolytica; modeling in vitro the prerequisites of the oxidative stress; control of the mitochondrial disfunctions by registration of membrane potential; testing pharmacological preparations under conditions of free radicals superproduction in mitochondria. The data obtained suggest that yeast mitochondrions having full competent respiratory chain, including complex I, may be used as a valuable model for studying processes provoked by oxidative stress and mitochondrial disfunctions, and for testing potential medicaments, for example, the neuroprotective preparations.