Аннотация:
ABSTRACT. The aim was to study an effect of various levels of lead nitrate in feed on the condition of red and white blood in experiment performed on sheep during 3 months. During this period, the clinical manifestations of lead toxicity in animals were not observed. The doses (on lead) 1 and 5 of the maximum permissible level (MPL) did not exert a negative effect on the number of red blood cells; dose 30 MPL reduced the number of erythrocytes and hemoglobin in the blood to concentrations corresponding to the lower limit of the physiological norm at the end of the first month of the experiment, followed by raising up to the initial level. The doses of lead 1 and 5 MPL did not have a negative impact on the morphological composition of white blood cells; 30 MPL caused a short-term decrease in the number of white blood cells to concentrations below the physiological norm. In groups 1 and 5 MPL, the number of leukocytes to the 90th day was close to the initial value; in group 30 MPL the number of leukocytes by this time reached the level of physiological norm but it was below the initial values (P<0.05). This group also noted a trend towards an increase in quantity of immature neutrophils. The data odtained suggest that intake in the diet of high doses of lead in the range of 5-30 MPL causes in sheep the transient negative changes in the state of peripheral blood.