Всероссийский научно-исследовательский институт физиологии, биохимии и питания животных – филиал Федерального государственного бюджетного научного учреждения «Федеральный научный центр животноводства – ВИЖ имени академика Л.К. Эрнста»
ABSTRACT. The aim of this work is the experimental testing the method of increasing stress resistance and productivity of pigs with the use of a new drug on the basis of lithium ascorbate. The experiment was carried out on 5 groups of gestating sows of Landrace breed in the second farrowing (4 test and 1 control group) by 5 sows each. After 30 days of fruitful insemination, the sows of I, II, III and IV groups received daily lithium ascorbate with food in powder form in the dose of 10; 5; 2; 0.5 mg/kg of live weight, respectively. Weighing was carried out before administration of the drug. Repeated weighing was performed after 2 and 3 months after fertilization and immediately before farrowing. Two months after fertilization and before farrowing, blood samples were taking for biochemical and hematological analysis. In the blood plasma were determined malonate dialdehyde, glutathione, triacylglycerole, total cholesterol, total protein, globulins of various fractions, fractions of lipoproteins (HDLP, LDLP, VLDLP), epinephrine, norepinephrine, cortisol and progesterone, thiol-disulfide ratio (SH/SS), activity of superoxide dismutase and glutathione peroxidase. It is established that lithium ascorbate, introduced to sows with feed at a dosage of 10, 5 and 2 mg/kg of body weight, exhibits a pronounced adaptogenic and stress-protective properties, prevents sudden releases of adrenaline and noradrenaline, supports at the physiological level the dynamics of cortisol and progesterone during pregnancy. In the experimental groups, more pigs per sow were obtained (P<0.05). Experimental data on the complex of endocrine, physiological and biochemical parameters indicate that lithium ascorbate in pregnant sows has a positive effect on lipid-cholesterol metabolism and antioxidant status, leades to an increase in live weight gain and improves the reproductive function of sows. The revealed effects of lithium ascorbate indicate the prospects of developing new effective ways of increasing stress-resistance, nonspecific resistance and productivity of animals by using products based on organic salts of lithium.
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